September 5, 2025Current Topics in Chemistry

Therapeutic Potential of Natural Compounds from Terminalia chebula in Managing Chronic Constipation: Insights from In Silico Studies Targeting the 5-HT4 Receptor

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Authors

SDSharmila Dusi JSJ. SaminathanDelhi Pharmaceutical Science and Research University SSS. SivakalaiDelhi Pharmaceutical Science and Research University

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Implication

In silico studies reveal TC24 from Terminalia chebula effectively modulates the 5-HT4 receptor, suggesting potential for managing chronic constipation symptoms.

Key Points

TC24 demonstrates a high binding affinity of -206.58 kcal/mol, indicating strong interaction with the 5-HT4 receptor.
Molecular dynamics simulations confirm complex stability, with minimal RMSD and RMSF deviations over 100 ns.
Thirty phytochemicals were screened using XP docking protocols, with TC24 emerging as the top compound.
Potential drug-likeness was assessed through Lipinski’s rule-of-five, supporting its oral bioavailability.

Cite This Study

Dusi et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477ca4d https://doi.org/10.2174/0129504023400474250818051128

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Implication

In silico studies reveal TC24 from Terminalia chebula effectively modulates the 5-HT4 receptor, suggesting potential for managing chronic constipation symptoms.

Therapeutic Potential of Natural Compounds from Terminalia chebula in Managing Chronic Constipation: Insights from In Silico Studies Targeting the 5-HT4 Receptor

Discussion

Member takes

Implication

Key Points

Cite This Study

Therapeutic Potential of Natural Compounds from Terminalia chebula in Managing Chronic Constipation: Insights from In Silico Studies Targeting the 5-HT4 Receptor

Discussion

Member takes

Implication

Key Points

Cite This Study

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