What does this research mean for the field?

Long-term glycemia trajectories do not confer an independent risk for cognitive impairment in adults with prediabetes or type 2 diabetes when accounting for established demographic, genetic, and cardiovascular risk factors. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 7, 2026Diabetes

2173-P: Twenty-Year Glycemia Trajectories and Risk for Cognitive Impairment (CI) in Adults with Prediabetes or Type 2 Diabetes (T2D) in the Diabetes Prevention Program Outcomes Study (DPPOS)

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Why the study?

Does HbA1c trajectory over 20 years increase the risk of cognitive impairment in adults with prediabetes or T2D?

Population

1,682 middle-aged adults with pre-diabetes at enrollment

Design

Cohort

Follow-up

20 years

Authors

ASAllison ShapiroColorado School of Public Health RSRICHARD SHUUniversity of Colorado Denver MTMarinella TemprosaMilken Institute

Discussion

Member takes

Implication

Long-term glycemia trajectories in prediabetes and T2D do not independently confer risk for cognitive impairment when accounting for established demographic, genetic, and cardiovascular risk factors.

Structured PICO

Does HbA1c trajectory over 20 years increase the risk of cognitive impairment in adults with prediabetes or T2D?

Population

1,682 middle-aged adults with pre-diabetes at enrollment

Intervention

HbA1c trajectory over 20 years of follow-up (intercept and slope)

Outcome

Prevalent cognitive impairment (CI) assessed via the National Alzheimer’s Coordinating Center Uniform Data Set (v3) 25 years after enrollmenthard clinical

Long-term glycemia trajectories in prediabetes and T2D do not independently confer risk for cognitive impairment when accounting for established demographic, genetic, and cardiovascular risk factors.

Cite This Study

Shapiro et al. (2026) studied this question.

synapsesocial.com/papers/6a250cd27def13d035e1d0e5 https://doi.org/10.2337/db26-2173-p

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Implication

Long-term glycemia trajectories in prediabetes and T2D do not independently confer risk for cognitive impairment when accounting for established demographic, genetic, and cardiovascular risk factors.

2173-P: Twenty-Year Glycemia Trajectories and Risk for Cognitive Impairment (CI) in Adults with Prediabetes or Type 2 Diabetes (T2D) in the Diabetes Prevention Program Outcomes Study (DPPOS)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

2173-P: Twenty-Year Glycemia Trajectories and Risk for Cognitive Impairment (CI) in Adults with Prediabetes or Type 2 Diabetes (T2D) in the Diabetes Prevention Program Outcomes Study (DPPOS)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider