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June 7, 2026Diabetes

1136-OR: Longitudinal Time-to-Event Modeling and Identification of Risk Factors for the Occurrence of Microvascular Complications in Youth-Onset Type 2 Diabetes

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Population

677 participants with youth-onset type 2 diabetes from the TODAY clinical trial

Design

Cohort

Follow-up

median 6-year

Authors

SHSEJUNG HWANGEYEunsol YangXLXing Luu

Discussion

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Overview

A parametric model identified baseline ALT and HbA1c, as well as early changes in BMI, blood pressure, and HbA1c, as key predictors of microvascular complications in youth-onset type 2 diabetes.

Structured PICO

P
Population
677 participants with youth-onset type 2 diabetes from the TODAY clinical trial
O
Outcome
Occurrence of microvascular complications (nephropathy, neuropathy, and retinopathy)composite

A parametric model identified baseline ALT and HbA1c, as well as early changes in BMI, blood pressure, and HbA1c, as key predictors of microvascular complications in youth-onset type 2 diabetes.

Cite This Study

HWANG et al. (2026) studied this question.

synapsesocial.com/papers/6a250cbc7def13d035e1cf17https://doi.org/10.2337/db26-1136-or
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 12087-P: Predictive Modeling of HbA1c Progression for Use in Synthetic Controls in Youth-Onset Type 2 Diabetes2026
  2. 22401-P: Genetic Regulation of Molecular Traits Enhances Precision Risk Stratification in Youth-Onset Type 2 Diabetes2026
  3. 32321-P: Machine-Learning Modeling for T2DM Prediction in over 3 Million Adults2026
  4. 42983-LB: Trajectories of Risk Factors among Participants with Long-Duration Type 1 Diabetes2026
  5. 52965-LB: Cardiovascular Disease Risk Prediction in Type 1 Diabetes over 30 Years2026