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June 6, 2026Blood

Histidine‑rich Glycoprotein Modulates Platelet Adhesion and Aggregation by Binding to GPIbα and GPIIb/IIIa

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Authors

RMRida MalikJZJi ZhouMNMiguel A.D. Neves

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Overview

Randomized trial demonstrates HRG influences platelet adhesion in humans, suggesting implications for coagulation disorders.

Key Points

  • The research aims to understand how histidine-rich glycoprotein (HRG) affects platelet adhesion and aggregation through its interaction with specific receptors.
  • Investigated HRG binding to GPIbα and GPIIb/IIIa using human and murine platelets.
  • Assessed platelet function in flow systems and microperfusion chambers under varying conditions.
  • Examined HRG levels in patients with sepsis or COVID-19 compared to healthy controls.
  • HRG binds to GPIbα on resting platelets and GPIIb/IIIa on activated platelets; binding decreases platelet aggregation.
  • HRG reduces von Willebrand factor and fibrinogen binding to platelet receptors, resulting in decreased thrombus growth.
  • Plasma HRG levels are significantly lower in patients with sepsis or COVID-19, promoting hyperreactive platelets.

Cite This Study

Malik et al. (2026) studied this question.

synapsesocial.com/papers/6a23b9ca71a5da9775e759c0https://doi.org/10.1182/blood.2026033144
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