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September 12, 2025CellsOpen Access

ApoC3 Attenuates Platelet Activation Through GPIIb/IIIa Receptor Interaction

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Authors

MHMichael HolzerEKEva KnuplezSĆSanja Ćurčić

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Overview

Analysis shows apoc3 reduces platelet activation through gpiib/iiia interactions, indicating a role in thrombotic risk.

Key Points

  • ApoC3 inhibits platelet activation significantly, showing a 70% reduction in response to ADP.
  • Depletion of apoC3 enhances platelet aggregation by over 25%, revealing its regulatory role.
  • The interaction of apoC3 with GPIIb/IIIa is crucial for its effects on platelet function.
  • These findings suggest apoC3 is linked to thrombotic risk and vascular health.

Cite This Study

Holzer et al. (2025) studied this question.

synapsesocial.com/papers/68d41ee1713b0b5dfea682dehttps://doi.org/10.3390/cells14181411
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Apolipoprotein C3 Promotes Angiogenesis in an Inflammatory Mouse Model of Peripheral Artery Disease2025
  2. 2Elevated apolipoprotein C3 heightens atherosclerosis risk by mediating arterial accumulation of free cholesterol and local inflammation in diabetes2025
  3. 3A murine monoclonal antibody to integrin αIIbβ3 that inhibits protein disulfide isomerase binding to platelets and platelet aggregation2025
  4. 4Integrin αvβ3 Antagonist Ameliorates Atherosclerotic Progression by Reducing Platelet Hyperactivation2025
  5. 5Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy2026