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May 30, 2026Echocardiography

Left atrial strain predicted the composite of all-cause death and heart failure hospitalizations in populations with and without cardiovascular conditions (HR 0.91; 95% CI 0.86-0.96).

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Why the study?

Does left atrial strain predict the composite of all-cause death and heart failure hospitalizations in populations with and without specific cardiovascular diseases?

Population

13,156 participants from 16 reports, including populations with and without specific cardiovascular diseases…

Design

Meta-analysis

Key result

Left atrial strain predicted the composite of all-cause death and heart failure hospitalizations in populations with and without cardiovascular conditions (HR 0.91; 95% CI 0.86-0.96).

Authors

FRFrancesca RizzettoCMCaterina MaffeisECErberto Carluccio

Discussion

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Overview

May enhance risk stratification beyond LVEF and LAV; leaves open prospective validation before clinical adoption.

Key Points

  • This research aims to evaluate the relationship between left atrial strain and major cardiovascular events in various populations, including those with cardiovascular conditions.
  • Systematic search conducted on PUBMED, COCHRANE, and WoS up to October 2023.
  • Studies included if they assessed left atrial strain and cardiovascular outcomes using speckle-tracking echocardiography.
  • Meta-analysis performed on 16 reports including 13156 participants, following the PRISMA framework.
  • Left atrial strain predicted cardiovascular outcomes with an HR of 0.91 (95% CI 0.86-0.96).
  • In heart failure patients, LAS showed an HR of 0.93 (95% CI 0.89-0.97) indicating strong predictive value.
  • For ischemic heart disease and valvular heart disease, LAV had HRs of 0.95 (95% CI 0.91-0.99) and 0.94 (95% CI 0.90-0.97) respectively.

Study Design

Type

Meta-Analysis (n=13,156)

Structured PICO

Does left atrial strain predict the composite of all-cause death and heart failure hospitalizations in populations with and without specific cardiovascular diseases?

P
Population
13,156 participants from 16 reports, including populations with and without specific cardiovascular diseases (heart failure, ischemic heart disease, valvular heart disease, left ventricular hypertrophy) across the range of left ventricular ejection fraction.
I
Intervention
Left atrial strain (LAS) measured by speckle-tracking echocardiography and analyzed as a continuous variable
O
Outcome
Composite of all-cause death and heart failure (HF) hospitalizationscomposite

Main Result

Effect estimate: HR 0.91 (95% CI 0.86-0.96)

Left atrial strain measured by speckle-tracking echocardiography is a significant predictor of all-cause death and heart failure hospitalizations across various cardiovascular conditions and LVEF ranges.

Cite This Study

Rizzetto et al. (2026) conducted a meta-analysis in Populations with and without specific cardiovascular diseases (n=13,156). Left atrial strain (LAS) was evaluated on Composite of all-cause death and heart failure (HF) hospitalizations (HR 0.91, 95% CI 0.86-0.96). Left atrial strain predicted the composite of all-cause death and heart failure hospitalizations in populations with and without cardiovascular conditions (HR 0.91; 95% CI 0.86-0.96).

synapsesocial.com/papers/6a1a80730307b785094326ebhttps://doi.org/10.1111/echo.70471
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