What is the clinical evidence from this study?

Study design: Cohort. Population: Early-onset primary liver cancer (n=3661). Intervention: Non-Hispanic Black race/ethnicity vs. Non-Hispanic White race/ethnicity. Primary outcome: Overall survival (HR 1.60, 95% CI 1.41-1.81, p=<0.001).

What does this research mean for the field?

Significant racial and ethnic disparities in overall and cancer-specific survival exist among patients with early-onset primary liver cancer, with Non-Hispanic Black patients experiencing the highest mortality risk independent of stage at diagnosis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research investigates the differences in survival rates by race and ethnicity among patients diagnosed with early-onset primary liver cancer.

May 30, 2026Journal of Clinical Oncology

Non-Hispanic Black race was associated with significantly worse overall survival compared to Non-Hispanic White race in early-onset primary liver cancer (HR 1.60; 95% CI 1.41-1.81; p<0.001).

Q: What are the key findings of this study?

Q: What does this research mean for the field?

Significant racial and ethnic disparities in overall and cancer-specific survival exist among patients with early-onset primary liver cancer, with Non-Hispanic Black patients experiencing the highest mortality risk independent of stage at diagnosis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

This research investigates the differences in survival rates by race and ethnicity among patients diagnosed with early-onset primary liver cancer.

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Why the study?

Do racial and ethnic disparities affect survival in patients with early-onset primary liver cancer?

Population

3,661 patients aged < 50 years with primary liver cancer diagnosed between 2006 and 2021 from the SEER…

Design

Cohort

Follow-up

up to 60 months

Key result

Non-Hispanic Black race was associated with significantly worse overall survival compared to Non-Hispanic White race in early-onset primary liver cancer (HR 1.60; 95% CI 1.41-1.81; p<0.001).

Authors

AGArup Ganguly VAVaidarshi Abbagoni ASAshish Sharma

Discussion

Member takes

Overview

Worse OS persists among Non-Hispanic Black patients; hypothesis-generating for equity interventions and causal mechanisms.

Key Points

This research investigates the differences in survival rates by race and ethnicity among patients diagnosed with early-onset primary liver cancer.
Analyzed patients under 50 with primary liver cancer from 2006 to 2021 using the SEER database.
Compared stage at diagnosis across racial/ethnic groups using chi-square testing.
Estimated overall and cancer-specific survival with Kaplan–Meier methods and utilized multivariable Cox models for analysis.
Median overall survival for Non-Hispanic Black patients was 9 months compared to 22 months for Non-Hispanic White patients.
Adjusted analysis revealed worse overall survival for Non-Hispanic Black (HR 1.60), Asian/Pacific Islander (HR 1.23), and Hispanic (HR 1.23) patients compared to Non-Hispanic White.
Cancer-specific survival disparities were most pronounced in Non-Hispanic Black patients with an HR of 2.19.

Study Design

Type

Cohort (n=3,661)

Multicenter

Yes

Structured PICO

Do racial and ethnic disparities affect survival in patients with early-onset primary liver cancer?

Population

3,661 patients aged < 50 years with primary liver cancer diagnosed between 2006 and 2021 from the SEER database.

Outcome

Overall survival (OS) and cancer-specific survival (CSS; liver cancer death)hard clinical

Main Result

Effect estimate: HR 1.60 (95% CI 1.41-1.81)

Absolute Event Rate: 21% vs 34.3%

p-value: p=<0.001

Significant racial and ethnic disparities in overall and cancer-specific survival persist among patients with early-onset primary liver cancer, independent of stage at diagnosis.

Cite This Study

Ganguly et al. (2026) conducted a cohort in Early-onset primary liver cancer (n=3,661). Non-Hispanic Black race/ethnicity vs. Non-Hispanic White race/ethnicity was evaluated on Overall survival (HR 1.60, 95% CI 1.41-1.81, p=<0.001). Non-Hispanic Black race was associated with significantly worse overall survival compared to Non-Hispanic White race in early-onset primary liver cancer (HR 1.60; 95% CI 1.41-1.81; p<0.001).

synapsesocial.com/papers/6a1a7f410307b785094318f1 https://doi.org/10.1200/jco.2026.44.16_suppl.e13749

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May 30, 2026Journal of Clinical Oncology

Non-Hispanic Black race was associated with significantly worse overall survival compared to Non-Hispanic White race in early-onset primary liver cancer (HR 1.60; 95% CI 1.41-1.81; p<0.001).

View Full Paper

Ask AI

Bookmark

Why the study?

Do racial and ethnic disparities affect survival in patients with early-onset primary liver cancer?

Population

3,661 patients aged < 50 years with primary liver cancer diagnosed between 2006 and 2021 from the SEER…

Design

Cohort

Follow-up

up to 60 months

Key result

Non-Hispanic Black race was associated with significantly worse overall survival compared to Non-Hispanic White race in early-onset primary liver cancer (HR 1.60; 95% CI 1.41-1.81; p<0.001).

Authors

AGArup Ganguly VAVaidarshi Abbagoni ASAshish Sharma

Discussion

Member takes

Overview

Worse OS persists among Non-Hispanic Black patients; hypothesis-generating for equity interventions and causal mechanisms.

Key Points

This research investigates the differences in survival rates by race and ethnicity among patients diagnosed with early-onset primary liver cancer.
Analyzed patients under 50 with primary liver cancer from 2006 to 2021 using the SEER database.
Compared stage at diagnosis across racial/ethnic groups using chi-square testing.
Estimated overall and cancer-specific survival with Kaplan–Meier methods and utilized multivariable Cox models for analysis.
Median overall survival for Non-Hispanic Black patients was 9 months compared to 22 months for Non-Hispanic White patients.
Adjusted analysis revealed worse overall survival for Non-Hispanic Black (HR 1.60), Asian/Pacific Islander (HR 1.23), and Hispanic (HR 1.23) patients compared to Non-Hispanic White.
Cancer-specific survival disparities were most pronounced in Non-Hispanic Black patients with an HR of 2.19.

Study Design

Type

Cohort (n=3,661)

Multicenter

Yes

Structured PICO

Do racial and ethnic disparities affect survival in patients with early-onset primary liver cancer?

Population

3,661 patients aged < 50 years with primary liver cancer diagnosed between 2006 and 2021 from the SEER database.

Outcome

Overall survival (OS) and cancer-specific survival (CSS; liver cancer death)hard clinical

Main Result

Effect estimate: HR 1.60 (95% CI 1.41-1.81)

Absolute Event Rate: 21% vs 34.3%

p-value: p=<0.001

Significant racial and ethnic disparities in overall and cancer-specific survival persist among patients with early-onset primary liver cancer, independent of stage at diagnosis.

Cite This Study

synapsesocial.com/papers/6a1a7f410307b785094318f1 https://doi.org/10.1200/jco.2026.44.16_suppl.e13749

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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