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May 22, 2026Journal of Translational MedicineOpen Access

Each 5-point increase in OBS was associated with lower odds of CMM (OR = 0.96) and reduced risks of all-cause mortality (HR = 0.85).

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Why the study?

Is a higher oxidative balance score associated with reduced cardiometabolic multimorbidity and mortality in NHANES participants?

Population

11,365 NHANES participants, median age 45 years, 52.55% male

Comparison

Higher oxidative balance score (OBS) vs Lower oxidative balance score (OBS)

Design

Cohort

Authors

STSiyuan TanGZGaoming ZengTHTing Huang

Discussion

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Overview

Higher OBS may support CMM risk reduction efforts; leaves open causality and interventional benefits in cardiometabolic populations.

Structured PICO

Is a higher oxidative balance score associated with reduced cardiometabolic multimorbidity and mortality in NHANES participants?

P
Population
11,365 NHANES participants, median age 45 years, 52.55% male
I
Intervention
Higher oxidative balance score (OBS)
C
Comparator
Lower oxidative balance score (OBS)
O
Outcome
Cardiometabolic multimorbidity (CMM) and all-cause mortalityhard clinical

Higher oxidative balance score is associated with lower cardiometabolic multimorbidity prevalence and reduced mortality risk, partially mediated by inflammatory and insulin resistance pathways.

Cite This Study

Tan et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff327d674f7c03778ba03https://doi.org/10.1186/s12967-026-08291-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between oxidative balance score and mortality: Prospective cohort study in a representative US population2025 · 1 citations
  2. 2Association between oxidative balance score with cardiovascular - kidney - metabolic syndrome and all-cause mortality among US population2025 · 1 citations
  3. 3Association between the oxidative balance score and all-cause mortality in patients with cardiovascular disease-cancer comorbidity2026
  4. 4Association of Oxidative Balance Score With All-Cause and Cardiovascular Mortality Among Hypertensive Adults2025
  5. 5The association between oxidative balance score and all-cause and cardiovascular mortality in patients with arthritis: a retrospective cohort study based on the NHANES database (1999–2018)2025