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January 8, 2026Journal of Health Population and NutritionOpen Access

Association between the oxidative balance score and all-cause mortality in patients with cardiovascular disease-cancer comorbidity

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Key result

Higher Oxidative Balance Score (OBS) reduced all-cause mortality risk by 22% compared to the lowest tertile in patients with cardiovascular disease-cancer comorbidity (HR 0.78).

Authors

FLFen LiuJWJian WangSWSi-ao WEN

Discussion

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Overview

Study demonstrates an inverse relationship between oxidative balance score and mortality in patients with cardiovascular disease-cancer comorbidity, implying potential predictive value of machine...

Key Points

  • To investigate the relationship between oxidative balance score and all-cause mortality in patients with cardiovascular disease and cancer comorbidity.
  • Analyzed data from patients with cardiovascular disease and cancer comorbidity.
  • Calculated oxidative balance scores for participants.
  • Developed a machine learning model to predict comorbidity outcomes.
  • Higher oxidative balance scores are significantly associated with lower all-cause mortality.
  • The machine learning model effectively predicts comorbidity outcomes.

Study Design

Type

Cohort (n=19,424)

Multicenter

No

PICO

P
Population
Cardiovascular disease-cancer comorbidity (n=19,424)
I
Intervention / Comparator
Oxidative Balance Score (OBS) vs Lowest tertile of OBS score
O
Primary Outcome
All-cause mortality — HR 0.78 (0.64–0.95), p=0.016

Main Result

Effect estimate: HR 0.78 (95% CI 0.64–0.95)

p-value: p=0.016

Limitations

  • Relatively small number of patients with specific CVD-cancer comorbidity may limit statistical power.
  • Cross-sectional design precludes causal inference.
  • Residual confounding possible due to unmeasured factors.
  • OBS calculation limited by available data, not encompassing all oxidative stress-related dietary and lifestyle components.

Cite This Study

Liu et al. (2026) conducted a cohort in Cardiovascular disease-cancer comorbidity (n=19,424). Oxidative Balance Score (OBS) vs. Lowest tertile of OBS score was evaluated on All-cause mortality (HR 0.78, 95% CI 0.64–0.95, p=0.016). Higher Oxidative Balance Score (OBS) reduced all-cause mortality risk by 22% compared to the lowest tertile in patients with cardiovascular disease-cancer comorbidity (HR 0.78).

synapsesocial.com/papers/69608779fa51ca23bb98097fhttps://doi.org/10.1186/s41043-025-01213-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between oxidative balance score and mortality: Prospective cohort study in a representative US population2025 · 1 citations
  2. 2Association between oxidative balance score and cardiometabolic multimorbidity: differential mortality, mediation mechanisms, and machine learning insights2026
  3. 3Association between the oxidative balance score and all-cause and cardiovascular mortality in patients with cardiovascular-kidney-metabolic syndrome——a retrospective cohort study from the NHANES2025
  4. 4The relationship between Oxidation Balance Score and all-cause mortality in patients with hypertension: An observational study2025
  5. 5Association between oxidative balance score with cardiovascular - kidney - metabolic syndrome and all-cause mortality among US population2025 · 1 citations