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April 15, 2026BMC Cardiovascular DisordersOpen Access

Pulsed field ablation versus cryoballoon ablation for pulmonary vein isolation in atrial fibrillation: a systematic review and meta-analysis with subgroup analyses by AF type

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Authors

MAMohammad Al Diab Al AzzawiAGAbdallah Gamal GoudaHAHassan Alharthi

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Overview

A systematic review compares procedural outcomes of pulsed field ablation and cryoballoon ablation in atrial fibrillation, suggesting advantages for PFA.

Key Points

  • This study aims to compare pulsed field ablation and cryoballoon ablation for pulmonary vein isolation in atrial fibrillation regarding efficiency and safety.
  • Conducted a systematic review and meta-analysis of studies comparing pulsed field ablation (PFA) and cryoballoon ablation (CBA).
  • Included randomized and comparative cohort studies up to October 2025 from multiple databases.
  • Evaluated outcomes such as procedure duration, fluoroscopy time, complications, and atrial arrhythmia recurrence.
  • PFA shortened procedure duration compared to CBA by an average of 11.50 minutes.
  • PFA reduced the incidence of persistent phrenic nerve palsy significantly compared to CBA.
  • At 1 year, PFA showed lower total atrial arrhythmia and atrial fibrillation recurrence rates compared to CBA.

Cite This Study

Azzawi et al. (2026) studied this question.

synapsesocial.com/papers/69df2c01e4eeef8a2a6b0f8chttps://doi.org/10.1186/s12872-026-05839-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pulsed field <i>vs</i> cryoballoon ablation: A meta-analysis with Hartung–Knapp, subgroup, and meta-regression analyses2025
  2. 2Comparative procedural outcomes of pulsed field, cryoballoon, and radiofrequency ablation for paroxysmal atrial fibrillation: a 15-year single-centre experience2026
  3. 3Pulsed-field ablation versus thermal ablation in the management of atrial fibrillation: A narrative review2026
  4. 4Higher premature atrial contraction burden after radiofrequency ablation vs. pulsed field or cryoballoon ablation in paroxysmal atrial fibrillation: a 3-year follow-up retrospective study2025 · 1 citations
  5. 5Cryoballoon Versus Radiofrequency Ablation for Persistent Atrial Fibrillation: Meta‐Analysis of Randomized Trials2026