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December 19, 2025World Journal of Meta-AnalysisOpen Access

Pulsed field vs cryoballoon ablation: A meta-analysis with Hartung–Knapp, subgroup, and meta-regression analyses

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Authors

MKMirza Muhammad Hadeed KhawarSOSanjar OdilovUMUmer Farooque Memon

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Overview

Meta-analysis reveals pulsed field ablation improves arrhythmia-free survival in atrial fibrillation, suggesting effectiveness over cryoballoon ablation.

Key Points

  • This research aims to compare the effectiveness and safety of pulsed field ablation versus cryoballoon ablation for treating atrial fibrillation.
  • Conducted a systematic review and meta-analysis of studies comparing PFA and CBA.
  • Searched multiple databases for studies up to August 2025.
  • Calculated pooled mean differences and odds ratios using random-effects models.
  • PFA significantly reduced procedure time by approximately 15.24 minutes.
  • Improved arrhythmia-free survival with an odds ratio of 1.27.
  • Lowered the risk of phrenic nerve palsy with an odds ratio of 0.17 compared to CBA.

Cite This Study

Khawar et al. (2025) studied this question.

synapsesocial.com/papers/69449a892f0218eca95083edhttps://doi.org/10.13105/wjma.v13.i4.115195
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.1991 · 7,528 citations
  2. 2Worldwide Epidemiology of Atrial Fibrillation2013 · 4,597 citations
  3. 3Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement2009 · 83,711 citations
  4. 4Measuring inconsistency in meta-analyses2003 · 64,184 citations
  5. 5Pulsed-field vs. cryoballoon vs. radiofrequency ablation: a propensity score matched comparison of one-year outcomes after pulmonary vein isolation in patients with paroxysmal atrial fibrillation2023 · 64 citations