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October 9, 2025Circulation Research

Abstract Wed099: Endothelial KLF4 regulates heart failure with preserved ejection fraction

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Authors

TDTapatee DasBrown UniversityYNYosuke NagaiJikei University School of MedicineXLXudong LiaoBrown University

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Implication

Endothelial KLF4 impacts HFpEF outcomes in transgenic mice, suggesting therapeutic potential.

Key Points

  • Endothelial KLF4 levels are crucial in heart failure with preserved ejection fraction outcomes.
  • Improvement in echocardiographic parameters and coronary flow reserve was seen in mice overexpressing KLF4.
  • Spatial single-cell RNA sequencing revealed insights into endothelial dysfunction's role in HFpEF.
  • These findings point to the endothelium and KLF4 as potential targets for heart failure therapy.

Cite This Study

Das et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fbe5https://doi.org/10.1161/res.137.suppl_1.wed099
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