C-C Chemokine Receptor 5 Deficiency Impairs Cardiac and Metabolic Homeostasis, Driving Heart Failure with Preserved Ejection Fraction-like Pathophysiology

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Discussion

Observational analysis showed CCR5 deficiency drives heart failure and metabolic dysregulation in mice, suggesting critical roles in cardiac health.

Heart failure with preserved ejection fraction-like features emerged from CCR5 deficiency, impacting metabolic homeostasis.
IL-1β and IL-6 levels rose significantly alongside increased fibrosis in CCR5 knockout mice.
Assessment revealed alterations in calcium-handling proteins, driving cardiac contractility changes associated with heart failure.
Findings suggest that targeting CCR5 may provide insights into managing heart failure and related metabolic disorders.

Po‐Shiuan Hsieh (2025) studied this question.

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Observational analysis showed CCR5 deficiency drives heart failure and metabolic dysregulation in mice, suggesting critical roles in cardiac health.