Molecular engineering of lysosome-based degraders unveils a rapidly expanding therapeutic strategy

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Small-Molecule Ligands Targeting Lysosome-Shuttling Receptors and the Emerging Landscape of Lysosome-Targeting Chimeras2025
2. 2LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation2025
3. 3Molecular erasers: Reprogramming cancer immunity through protein degradation2025
4. 4Targeted degradation of cell surface proteins through endocytosis triggered by cell-penetrating peptide-small molecule conjugates2025
5. 5A Tumor-Specific Membrane Protein Degradation Platform via Covalent Reaction-Induced Aggregation2025