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September 10, 2025Nature CommunicationsOpen Access

Targeted degradation of cell surface proteins through endocytosis triggered by cell-penetrating peptide-small molecule conjugates

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Authors

WHWanyi HeCCCongli ChenJZJiwei Zheng

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Overview

Observational analysis highlights efficient degradation of plasma membrane proteins via CPPTACs, suggesting broader therapeutic applications.

Key Points

  • CPPTACs demonstrate a remarkable ability to degrade clinically significant plasma membrane proteins, including PD-L1 and CAIX.
  • The study reveals that CPPTACs degrade targets without relying on specific lysosome-targeting receptors, broadening their applicability.
  • This method showcases a simpler structural design compared to LYTACs, enabling more accessible drug development strategies.
  • CPPTACs consist of bioactive small molecules combined with cell-penetrating peptides, offering an effective approach for protein degradation.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/68c2427db210217d647a4304https://doi.org/10.1038/s41467-025-62776-w
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