What question did this study set out to answer?

The research aims to evaluate the impact of gene deletions in ASFV and their effects on pathogenicity and immunity in pigs.

January 9, 2026Emerging Microbes & InfectionsOpen Access

The Deletion of the EP402R and MGF505/360 Genes Attenuates a Genotype I/II Recombinant ASFV but Fails to Confer Complete Protection against Homologous or Genotype II Challenge in Pigs

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Key result

Deletion of EP402R and MGF505/360 genes in ASFV-HNΔCD2vΔMGF significantly reduced virulence in pigs, but failed to confer full protection against lethal ASFV challenges.

Authors

YLYao LiShanghai Veterinary Research Institute YLYingnan LiuAnhui Agricultural University ZSZhuyun SunShanghai Veterinary Research Institute

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Implication

Demonstrates gene deletion effects on ASFV virulence in pigs, indicating gaps in protection against challenges.

Key Points

The research aims to evaluate the impact of gene deletions in ASFV and their effects on pathogenicity and immunity in pigs.
Constructed two gene-deleted ASFV strains (ASFV-HNΔMGF and ASFV-HNΔCD2vΔMGF) from the ASFV-HN strain.
Inoculated pigs with gene-deleted strains to assess pathogenicity and survival rates.
Challenged surviving pigs with parental and other virulent ASFV strains to evaluate protective immunity.
ASFV-HNΔMGF exhibited pathogenicity, with affected pigs showing symptoms.
ASFV-HNΔCD2vΔMGF displayed significantly reduced virulence, with all pigs surviving infections.
Neither gene deletion provided complete protection against subsequent challenges from ASFV-HN or the II-type strain ASFV-GZ.

Cite This Study

Li et al. (2025) studied this question. Deletion of EP402R and MGF505/360 genes in ASFV-HNΔCD2vΔMGF significantly reduced virulence in pigs, but failed to confer full protection against lethal ASFV challenges.

synapsesocial.com/papers/69612fe730ef6c21f6853fbe https://doi.org/10.1080/22221751.2025.2608396

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The Deletion of the EP402R and MGF505/360 Genes Attenuates a Genotype I/II Recombinant ASFV but Fails to Confer Complete Protection against Homologous or Genotype II Challenge in Pigs

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Key Points

Cite This Study

The Deletion of the EP402R and MGF505/360 Genes Attenuates a Genotype I/II Recombinant ASFV but Fails to Confer Complete Protection against Homologous or Genotype II Challenge in Pigs

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Implication

Key Points

Cite This Study

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