September 10, 2025Journal of VirologyOpen Access

An attenuated African swine fever virus with deletions of the CD2v and A137R genes offers complete protection against homologous challenge in pigs

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Discussion

Recombinant vaccine shows complete protection against homologous ASF virus challenge in pigs, suggesting effectiveness.

Complete protection was observed in all pigs after challenge with ASF virus, indicating potential for use as a vaccine.
Four out of four pigs remained healthy during a 27-day period after inoculation with the modified virus, showing successful attenuation.
Pathogen encoding regions CD2v and A137R were deleted to reduce virulence, leading to improved immune responses in swine.
Findings support further development of live-attenuated vaccines against African swine fever virus in commercial applications.

Peng et al. (2025) studied this question.

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