What type of study is this?

This is a In Vitro Study study.

December 4, 2025VirusesOpen Access

Evaluation of the Pathogenicity of Highly Virulent Eurasian Genotype II African Swine Fever Virus with MGF505-2R Gene Deletion in Piglets

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Evaluation shows reduced pathogenicity in piglets inoculated with recombinant ASFV, suggesting safer vaccine development.

ASFV-ΔMGF505-2R inoculated piglets showed only transient fever with limited viral loads at challenge onset.
Control group developed high viremia and severe symptoms by days 2 and 8, highlighting pathogenicity differences.
Recombinant viral strain with gene deletion was analyzed for immune responses and clinical outcomes in piglets.
Findings support the potential use of ASFV-ΔMGF505-2R as a safer live attenuated vaccine candidate.

Xu et al. (2025) studied this question.

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