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January 9, 2026Biomolecules and BiomedicineOpen Access

Circulating microRNA-21 has significant diagnostic and prognostic value in heart failure.

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Key result

Circulating microRNA-21 has significant diagnostic and prognostic value in heart failure.

Authors

ANAnnisa Salsabilla Dwi NugrahaniWWWynne WidiartiRRRoy Novri Ramadhan

Discussion

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Overview

Systematic review and meta-analysis demonstrate circulating miR-21's promise in diagnosing heart failure, indicating its potential utility.

Key Points

  • To evaluate the diagnostic and prognostic value of circulating microRNA-21 in heart failure populations.
  • Conducted a systematic review and meta-analysis of 14 studies
  • Estimated pooled sensitivity, specificity, and area under the curve for diagnostic accuracy
  • Synthesized hazard ratios for prognostic outcomes
  • Performed univariate meta-regression to examine moderating factors
  • Circulating miR-21 levels were significantly elevated in heart failure patients compared to controls (fold change 1.61)
  • Diagnostic accuracy showed sensitivity of 0.94 and specificity of 0.90
  • Area under the curve was 0.97, indicating high diagnostic precision
  • Higher miR-21 levels correlated with increased risk for worsening heart failure severity (HR 1.84)
  • No significant association found with heart failure-related hospitalization (HR 0.97)

Study Design

Type

Meta-Analysis

PICO

P
Population
Heart failure
I
Intervention / Comparator
Circulating microRNA-21
O
Primary Outcome
Diagnostic and prognostic value of circulating microRNA-21

Limitations

  • High confounding risk in some studies.

Cite This Study

Nugrahani et al. (2025) conducted a meta-analysis in Heart failure. Circulating microRNA-21 was evaluated on Diagnostic and prognostic value of circulating microRNA-21. Circulating microRNA-21 has significant diagnostic and prognostic value in heart failure.

synapsesocial.com/papers/69612fe430ef6c21f6853f64https://doi.org/10.17305/bb.2025.13164
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of microRNA-19b, microRNA-21, and microRNA-208a in diagnosis of heart failure2025 · 1 citations
  2. 2New Frontiers of microRNA in Heart Failure: From Clinical Risk to Therapeutic Applications2025 · 7 citations
  3. 3Clinical significance and correlation of microRNA-21 expression in patients undergoing transcatheter aortic valve replacement2025
  4. 4Comprehensive Profiling Identifies Circulating microRNA Dysregulation in Vietnamese Patients with Heart Failure2025 · 5 citations
  5. 5miR-30c-5p serves a diagnostic biomarker in chronic heart failure patients and its regulatory role in vascular endothelial2025 · 1 citations