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September 18, 2025Turkish Journal of BiochemistryOpen Access

miR-30c-5p serves a diagnostic biomarker in chronic heart failure patients and its regulatory role in vascular endothelial

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Authors

DXDan XiongYMYi MeiYZYao Zhu

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Overview

Analysis shows miR-30c-5p levels diagnose chronic heart failure in patients, indicating its role in vascular endothelial function.

Key Points

  • Serum levels of miR-30c-5p decrease as chronic heart failure progresses, indicating its potential as a diagnostic biomarker.
  • With a diagnostic accuracy of 83.19% sensitivity and 84.69% specificity, miR-30c-5p is pivotal for identifying CHF.
  • The approach included RT-qPCR and logistic regression analysis in 113 CHF patients compared to 98 healthy individuals.
  • Reduced miR-30c-5p may influence the development of CHF by impacting the function of vascular endothelial cells.

Cite This Study

Xiong et al. (2025) studied this question.

synapsesocial.com/papers/68d435dd713b0b5dfea7547dhttps://doi.org/10.1515/tjb-2025-0033
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Also Consider

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  1. 1miR-3150b-3p Promotes Vascular Smooth Muscle Cell Injury by Targeting ARL5B2025
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  5. 5Dysregulation of Serum miR-212-3p Serves as a Biomarker to Predict Disease Onset and Short-Term Prognosis in Acute Coronary Syndrome Patients2025