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August 26, 2025AJP Heart and Circulatory PhysiologyOpen Access

Clinical significance and correlation of microRNA-21 expression in patients undergoing transcatheter aortic valve replacement

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Authors

ABAnat BerkovitchZSZvi SirotkinYGYoni Grossman

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Overview

Observational analysis revealed significant correlation between microRNA-21 levels and MACCE in patients undergoing TAVR, suggesting it may assist in risk stratification.

Key Points

  • A significant decrease in microRNA-21 at 6 hours post-TAVR correlates with higher MACCE rates and 30-day mortality.
  • Patients with an RQ of miR-21 below 0.709 faced 40% MACCE rates versus 16% in those with stable levels.
  • Analysis of 76 patients assessed miRNA levels pre- and post-TAVR using PCR techniques for prognostic evaluation.
  • Recommendations point to microRNA-21 as a potential biomarker for personalized management following TAVR.

Cite This Study

Berkovitch et al. (2025) studied this question.

synapsesocial.com/papers/68af7dec7567bf4f94ff4856https://doi.org/10.1152/ajpheart.00506.2025
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