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January 9, 2026International Journal of Medicine and Health DevelopmentOpen Access

Vitamin D deficiency is linked to increased left ventricular mass index and reduced ejection fraction, but supplementation shows no significant improvement in LV parameters.

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Key result

Vitamin D deficiency is linked to increased left ventricular mass index and reduced ejection fraction, but supplementation shows no significant improvement in LV parameters.

Authors

RZRadhiah ZakariaASArtha Maressa Theodora SimanjuntakFWFrengki Prabowo Saputro Wijayanto

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Overview

A systematic review finds vitamin D deficiency harms cardiac function in hypertensive individuals, suggesting supplementation is ineffective.

Key Points

  • To evaluate the relationship between serum vitamin D levels and left ventricular remodeling in hypertensive individuals, and assess the effect of supplementation.
  • Systematic search across five databases following PRISMA guidelines
  • Included observational studies and clinical trials related to vitamin D and LV parameters
  • Calculated standardized mean differences and estimated heterogeneity using I² statistics
  • Significant association found between low vitamin D and increased LV mass index and dimensions (P < 0.001)
  • Inverse correlation between serum vitamin D and LVMI (r = −0.31, P < 0.001)
  • Lower vitamin D linked to reduced LV ejection fraction (SMD = −0.38, P = 0.038)
  • No significant effect of vitamin D supplementation observed in LVMI (SMD = 0.03, P = 0.753)

Cite This Study

Zakaria et al. (2025) studied this question. Vitamin D deficiency is linked to increased left ventricular mass index and reduced ejection fraction, but supplementation shows no significant improvement in LV parameters.

synapsesocial.com/papers/69612fe430ef6c21f6853f60https://doi.org/10.4103/ijmh.ijmh_113_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Associations of vitamin D with coronary revascularization and heart rate variability in hypertensive patients2025
  2. 2A Meta‐Analysis on the Effect of Vitamin D Supplementation on Endothelial Function in Adults2025
  3. 3Interaction between the non-alcoholic fatty liver disease fibrosis score and vitamin D deficiency on left ventricular hypertrophy and impaired diastolic function in patients with type 2 diabetes mellitus2025
  4. 4Effect of vitamin D supplementation for major adverse cardiovascular events: A meta-analysis based on randomized controlled trials2025
  5. 5Arterial Stiffness and Early Cardiac Dysfunction in Type 2 Diabetes Mellitus: A Potential Role for 25 OH Vitamin D3 Deficiency2025