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January 9, 2026Supportive Care in CancerOpen Access

The modified PCOQ demonstrated preliminary evidence of construct validity, with patients generally viewing lower symptom severity levels as acceptable, highlighting the priority of individualized symptom management in advanced prostate cancer.

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Key result

The modified PCOQ demonstrated preliminary evidence of construct validity, with patients generally viewing lower symptom severity levels as acceptable, highlighting the priority of individualized symptom management in advanced prostate cancer.

Authors

SSStella SnyderESEkin SeçintiEKEllen Krueger

Discussion

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Overview

Evaluates symptom severity and priorities in advanced prostate cancer, suggesting a need for tailored care strategies.

Key Points

  • The aim is to assess acceptable symptom levels and priorities for symptom improvement in advanced prostate cancer patients.
  • Conducted a one-time survey with 99 patients using a modified Patient-Centered Outcomes Questionnaire (PCOQ).
  • Included standard symptom measures and assessed clinical characteristics.
  • Identified patient subgroups based on their symptom importance ratings.
  • The modified PCOQ showed construct validity with significant correlations to related constructs.
  • Patients generally had low acceptable severity levels for symptoms, with sexual dysfunction rated higher.
  • Identified three subgroups: low importance (43 patients), moderate importance (33 patients), and high importance (18 patients) with different associations to functional status and emotional distress.

Study Design

Type

Observational (n=99)

Multicenter

No

PICO

P
Population
Advanced prostate cancer (n=99)
I
Intervention / Comparator
Patient-Centered Outcomes Questionnaire (PCOQ)
O
Primary Outcome
Acceptable symptom severity levels after symptom treatment across 10 symptoms, p=<0.01

Main Result

p-value: p=<0.01

Limitations

  • Limited to a single academic center
  • Sample homogeneity (mostly non-Hispanic White participants)
  • Small sample size may limit statistical power
  • Cross-sectional design did not assess longitudinal changes.

Cite This Study

Snyder et al. (2026) conducted an observational in Advanced prostate cancer (n=99). Patient-Centered Outcomes Questionnaire (PCOQ) was evaluated on Acceptable symptom severity levels after symptom treatment across 10 symptoms (p=<0.01). The modified PCOQ demonstrated preliminary evidence of construct validity, with patients generally viewing lower symptom severity levels as acceptable, highlighting the priority of individualized symptom management in advanced prostate cancer.

synapsesocial.com/papers/69612fd930ef6c21f6853d8ehttps://doi.org/10.1007/s00520-025-10299-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evolution of symptom burden across prostate cancer disease states in the EHR-facilitated Cancer Symptom Control (E2C2) trial.2026
  2. 2Domains of prognostic awareness, quality of life, and psychological distress in patients with advanced cancer2025
  3. 3Patient-Reported Outcomes as Prognostic Indicators for Overall Survival in Cancer2025 · 23 citations
  4. 4Association of social environment with clinically meaningful declines in health-related quality of life domain bother and function in individuals after prostate cancer treatment.2026
  5. 5Psychosocial factors associated with perceived cognitive functioning in prostate cancer survivors: an exploratory cross-sectional analysis2025 · 1 citations