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September 12, 2025JAMA Oncology

Patient-Reported Outcomes as Prognostic Indicators for Overall Survival in Cancer

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Authors

RHRyan S. HuangDCDavid ChenABAli Benour

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Overview

Systematic review and meta-analysis reveal patient-reported outcomes impact overall survival in cancer patients, suggesting clinical integration.

Key Points

  • Patients with higher global health status scores show improved overall survival, indicating the value of PROs.
  • Analysis of 69 randomized clinical trials found associations between quality of life and overall survival using hazard ratios.
  • Systematic review highlights that symptom burden negatively impacts overall survival, marking the need for better symptom management.
  • Integration of patient-reported outcomes into oncology can enhance clinical decision-making and patient care.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68d41bfb713b0b5dfea650dfhttps://doi.org/10.1001/jamaoncol.2025.3153
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