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May 30, 2026Journal of Clinical Oncology

High Social Vulnerability Index was associated with lower odds of discordant clinically meaningful change in the sexual domain (OR 0.35; 95% CI 0.16-0.73) two years after prostate cancer treatment.

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Why the study?

Does high social vulnerability index affect clinically meaningful changes in HRQoL-related function and bother in men after prostate cancer treatment?

Population

8,904 men after prostate cancer treatment from the CaPSURE registry, mean age 65.36 years, 86.5% White, 9.8%…

Comparison

High Social Vulnerability Index vs Lower Social Vulnerability Index

Design

Cohort

Follow-up

two years

Key result

High Social Vulnerability Index was associated with lower odds of discordant clinically meaningful change in the sexual domain (OR 0.35; 95% CI 0.16-0.73) two years after prostate cancer treatment.

Authors

DSDisha SrivastavaAJAngad JhandiTCTyler Cain

Discussion

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Overview

High social vulnerability is associated with worse baseline health-related quality of life and a greater risk of concurrent declines in both sexual function and bother after prostate cancer treatment.

Key Points

  • The aim is to analyze how social environment influences clinically meaningful changes in health-related quality of life post-prostate cancer treatment.
  • Analyzed deidentified patient data from CaPSURE registry linked with CDC Social Vulnerability Index (SVI) data.
  • Assessed health-related quality of life (HRQoL) using the UCLA Prostate Cancer Index before and two years after treatment.
  • Conducted multivariable logistic regressions to assess the relationship between SVI and discordant changes in HRQoL.
  • Among 8,904 men, 12.5% reported changes in urinary, 17.7% in sexual, and 9.5% in bowel domains after treatment.
  • High SVI patients showed worse baseline HRQoL scores and lower odds of discordant sexual HRQoL changes (OR 0.35, 95% CI 0.16-0.73).
  • Different treatment modalities were associated with varied odds of function decline in urinary, sexual, and bowel domains.

Study Design

Type

Cohort (n=8,904)

Multicenter

Yes

Structured PICO

Does high social vulnerability index affect clinically meaningful changes in HRQoL-related function and bother in men after prostate cancer treatment?

P
Population
8,904 men after prostate cancer treatment from the CaPSURE registry, mean age 65.36 years, 86.5% White, 9.8% Black.
I
Intervention
High Social Vulnerability Index (SVI ≥75th percentile nationally)
C
Comparator
Lower Social Vulnerability Index (<75th percentile)
O
Outcome
Discordant clinically meaningful changes in HRQoL-related function and bother (urinary, sexual, and bowel) at two years post-treatmentpatient reported

Main Result

Effect estimate: OR 0.35 (95% CI 0.16-0.73)

High social vulnerability is associated with worse baseline health-related quality of life and a greater risk of concurrent declines in both sexual function and bother after prostate cancer treatment.

Cite This Study

Srivastava et al. (2026) conducted a cohort in Prostate cancer (n=8,904). High Social Vulnerability Index (SVI) vs. Low SVI was evaluated on Discordant clinically meaningful change in sexual domain (OR 0.35, 95% CI 0.16-0.73). High Social Vulnerability Index was associated with lower odds of discordant clinically meaningful change in the sexual domain (OR 0.35; 95% CI 0.16-0.73) two years after prostate cancer treatment.

synapsesocial.com/papers/6a1a827f0307b78509434278https://doi.org/10.1200/jco.2026.44.16_suppl.e17025
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