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January 8, 2026Frontiers in Cardiovascular MedicineOpen Access

Inflammatory biomarkers as predictors of prognosis in patients after transcatheter aortic valve implantation

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Key result

SIRS is associated with a significantly higher risk of long-term adverse outcomes in patients after TAVI.

Authors

LVLuka VitezPMPeter M. MihailovicMBMojca Božič

Discussion

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Overview

Prospective cohort study shows inflammatory biomarkers predict outcomes in patients post-TAVI, implying better risk assessment.

Key Points

  • The aim is to identify inflammatory biomarkers that may predict long-term outcomes in patients after transcatheter aortic valve implantation (TAVI).
  • Single-center, prospective cohort design
  • 62 consecutive patients undergoing TAVI enrolled
  • Blood samples collected before TAVI, at 24 hours, and 3–6 months post-procedure
  • Analysis of biomarker levels and SIRS predictors
  • 45% of patients developed systemic inflammatory response syndrome (SIRS) post-TAVI
  • Elevated hs-CRP and IFN-γ levels were significantly associated with higher risk of adverse outcomes
  • Multivariable Cox analysis indicated strong predictive value of baseline hs-CRP and IFN-γ for long-term mortality or hospitalization

Study Design

Type

Cohort (n=62)

Multicenter

No

PICO

P
Population
Systemic inflammatory response syndrome (SIRS) after transcatheter aortic valve implantation (n=62)
I
Intervention / Comparator
Transcatheter aortic valve implantation (TAVI) vs No SIRS patients
O
Primary Outcome
All-cause mortality or unplanned hospitalization at 5 years — HR 3.07 (1.57–6.00), p=0.001

Main Result

Effect estimate: HR 3.07 (95% CI 1.57–6.00)

Absolute Event Rate: 35.8% vs 4.5%

p-value: p=0.001

Limitations

  • Single-center study
  • Limited sample size
  • No formal sample size calculation conducted.

Cite This Study

Vitez et al. (2026) conducted a cohort in Systemic inflammatory response syndrome (SIRS) after transcatheter aortic valve implantation (n=62). Transcatheter aortic valve implantation (TAVI) vs. No SIRS patients was evaluated on All-cause mortality or unplanned hospitalization at 5 years (HR 3.07, 95% CI 1.57–6.00, p=0.001). SIRS is associated with a significantly higher risk of long-term adverse outcomes in patients after TAVI.

synapsesocial.com/papers/69608779fa51ca23bb980992https://doi.org/10.3389/fcvm.2025.1722293
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circulating biomarkers improve prediction of postoperative outcome after aortic valve surgery2026
  2. 2Transcatheter Aortic Valve Replacement Outcomes in Patients with Chronic Inflammatory Systemic Diseases2026
  3. 3Inflammatory indices predict poor early outcomes after tricuspid valve surgery: A retrospective cohort study2025
  4. 4Prognostic impact of iliofemoral access-site calcification volume on outcomes after transcatheter aortic valve implantation2026
  5. 5Clinical significance and correlation of microRNA-21 expression in patients undergoing transcatheter aortic valve replacement2025