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June 19, 2026The American Journal of Cardiology

Transcatheter Aortic Valve Replacement Outcomes in Patients with Chronic Inflammatory Systemic Diseases

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Key result

Chronic inflammatory diseases in TAVR are linked to similar mortality but ~69% more vascular complications.

  • P=0.73
  • n=2,880

Why the study?

Does the coexistence of chronic inflammatory systemic diseases lead to worse clinical outcomes in patients undergoing TAVR?

Population

2,880 patients undergoing transcatheter aortic valve replacement, mean age 79±9 years, 45% female, 78%…

Comparison

Transcatheter aortic valve replacement in… vs Transcatheter aortic valve replacement in…

Design

Cohort

Follow-up

1 year

Authors

BVBeni VermaASAnita SadeghpourFHFarah Bani Hani

Discussion

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Overview

Similar one-year mortality supports TAVR in CID patients; leaves open effects on complications or longer-term outcomes.

Key Points

  • Evaluate the impact of chronic inflammatory systemic diseases on outcomes after transcatheter aortic valve replacement.
  • Retrospective analysis of 2,880 TAVR patients from 11/21/2011 to 03/29/2024.
  • Identified patients with chronic inflammatory diseases using ICD codes.
  • Compared clinical outcomes during inpatient and at one-year between CIDs and no-CID groups.
  • Higher proportion of females (61.6% vs 43.9%, p<0.001) and immunosuppressive therapy (5.9% vs 2.9%, p=0.02) among CIDs patients.
  • In-hospital mortality was similar (0.0% vs 1.7%; p=0.08); however, vascular complications (10.3% vs 6.1%, p=0.036) were more common in CIDs.
  • One-year mortality was comparable (8.9% vs 8.91%, log-rank p=0.73) between groups.

Study Design

Type

Cohort (n=2,880)

Multicenter

No

Structured PICO

Does the coexistence of chronic inflammatory systemic diseases lead to worse clinical outcomes in patients undergoing TAVR?

P
Population
2,880 patients undergoing transcatheter aortic valve replacement (mean age 79 years, 45% female), including 185 with chronic inflammatory systemic diseases, followed for one year.
E
Exposure
Transcatheter aortic valve replacement (TAVR) in patients with chronic inflammatory systemic diseases (CIDs)
C
Comparator
Transcatheter aortic valve replacement (TAVR) in patients without chronic inflammatory systemic diseases
O
Outcome
Clinical outcomes during inpatient and at one-year (including in-hospital mortality, vascular complications, unplanned vascular interventions, and one-year mortality)hard clinical

Main Result

Absolute Event Rate: 8.9% vs 8.91%

p-value: p=0.73

TAVR in patients with chronic inflammatory systemic diseases has comparable one-year mortality to those without, but carries a higher risk of vascular access complications.

Cite This Study

Verma et al. (2026) conducted a cohort in Aortic stenosis requiring transcatheter aortic valve replacement (n=2,880). Chronic inflammatory systemic diseases (CIDs) vs. No chronic inflammatory systemic diseases was evaluated on One-year mortality (p=0.73). In TAVR patients, chronic inflammatory systemic diseases were associated with similar one-year mortality (8.9% vs 8.91%, p=0.73) but higher vascular complications (10.3% vs 6.1%, p=0.036).

synapsesocial.com/papers/6a359a4add3be7785e70ee22https://doi.org/10.1016/j.amjcard.2026.06.010
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Short- and long-term outcomes after transcatheter or surgical aortic valve replacement in patients with chronic lung disease: An analysis from the German Aortic Valve Registry2025
  2. 2Inflammatory biomarkers as predictors of prognosis in patients after transcatheter aortic valve implantation2026
  3. 3Clinical Outcomes after Transcatheter Aortic Valve Implantation in Nonagenarian Patients: A Retrospective Population-Based Cohort Study2025
  4. 4Evaluating the Efficacy and Outcomes of Transcatheter Aortic Valve Replacement Versus Surgical Aortic Valve Replacement in Low‐ to Intermediate‐Risk Aortic Regurgitation Patients: A Comprehensive Clinical Comparison2026
  5. 5Clinical outcomes of percutaneous coronary interventions after transcatheter aortic valve replacement2025 · 1 citations