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January 6, 2026JAC-Antimicrobial ResistanceOpen Access

O04 Oral antimicrobial therapy for infective endocarditis: real-world experience from a teaching hospital in Scotland

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Authors

NRNikolas RaeEDEmma DuncanNSNeil Stevenson

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Overview

Retrospective review shows oral antimicrobial therapy improves outcomes in infective endocarditis patients, suggesting clinical efficacy but requiring regimen adjustments for linezolid.

Key Points

  • Evaluate the clinical efficacy and outcomes of oral antimicrobial therapy for infective endocarditis.
  • Retrospective review of clinical records from patients treated with oral antibiotics for infective endocarditis
  • Assessment of demographic data, endocarditis characteristics, and treatment modalities
  • Evaluation of adverse outcomes including mortality and complications within six months post-therapy
  • Of 29 patients, 76% met POET trial criteria; 72% were male with a mean age of 67
  • Average duration of oral therapy was 26 days, while IV therapy lasted an average of 15 days
  • Adverse outcomes included two embolic events and one death related to cardiac failure, with regimen alterations required mainly for linezolid due to adverse effects.

Cite This Study

Rae et al. (2026) studied this question.

synapsesocial.com/papers/695d85413483e917927a44d2https://doi.org/10.1093/jacamr/dlaf239.004
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Also Consider

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  1. 1Should we extend the use of oral antibiotics in infective endocarditis? The ENDO-ORAL study2025 · 5 citations
  2. 2Partial Oral Antibiotic Therapy in Infective Endocarditis: Evidence, Patient Selection, and Practical Implementation2026
  3. 3Increased role of oral antibiotics in the management of deep-seated infections2025 · 1 citations
  4. 4Antibacterial therapy for infective endocarditis: сurrent approaches and prospects2025 · 1 citations
  5. 5The promise and challenges of oral step-down therapy for infective endocarditis in South Africa – Rethinking endocarditis treatment2025