Should we extend the use of oral antibiotics in infective endocarditis? The ENDO-ORAL study

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Retrospective cohort assesses oral antibiotics effectiveness in infective endocarditis, suggesting broader use may be beneficial.

No significant difference in treatment failure was observed between intravenous and oral groups after adjustment, indicating similar effectiveness.
Days alive outside the hospital were significantly higher in the oral group, with an average of 59 days compared to 47 days for intravenous patients.
Analysis included 333 adults from two French centers treated for infective endocarditis, providing real-life data on oral therapy.
Results were consistent in the POET-ineligible subgroup, suggesting oral switch could extend treatment options for more patients.

Rallet et al. (2025) studied this question.

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View Full Paper

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Authors

Retrospective cohort assesses oral antibiotics effectiveness in infective endocarditis, suggesting broader use may be beneficial.

No significant difference in treatment failure was observed between intravenous and oral groups after adjustment, indicating similar effectiveness.
Days alive outside the hospital were significantly higher in the oral group, with an average of 59 days compared to 47 days for intravenous patients.
Analysis included 333 adults from two French centers treated for infective endocarditis, providing real-life data on oral therapy.
Results were consistent in the POET-ineligible subgroup, suggesting oral switch could extend treatment options for more patients.

Rallet et al. (2025) studied this question.

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