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September 5, 2025Singapore Medical JournalOpen Access

Increased role of oral antibiotics in the management of deep-seated infections

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Authors

ZTZhen Zhong Darren TeoHCHui Hiong ChenMKMatthew Chung Yi Koh

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Overview

Meta-analysis indicates oral antibiotics show comparable outcomes to IV treatment for deep-seated infections, suggesting a shift in management practices.

Key Points

  • Oral antibiotics can reduce hospital length of stay while effectively managing deep-seated infections.
  • The OVIVA trial demonstrated non-inferiority for early oral therapy in bone and joint infections with a treatment failure rate of PO 13.3% vs. IV 14.7%.
  • A meta-analysis of RCTs revealed oral antibiotics for Gram-negative bacteraemia achieve outcomes similar to IV therapy in selected patients.
  • Real-world applications of oral therapy for infective endocarditis indicate feasibility, although careful monitoring for toxicity is essential.

Cite This Study

Teo et al. (2025) studied this question.

synapsesocial.com/papers/68c23887b210217d64778418https://doi.org/10.4103/singaporemedj.smj-2025-017
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Should we extend the use of oral antibiotics in infective endocarditis? The ENDO-ORAL study2025 · 5 citations
  2. 2Partial Oral Antibiotic Therapy in Infective Endocarditis: Evidence, Patient Selection, and Practical Implementation2026
  3. 3O04 Oral antimicrobial therapy for infective endocarditis: real-world experience from a teaching hospital in Scotland2026
  4. 4The promise and challenges of oral step-down therapy for infective endocarditis in South Africa – Rethinking endocarditis treatment2025
  5. 5Patient-reported perceptions, experiences and preferences around intravenous and oral antibiotics for the treatment of <i>Staphylococcus aureus</i> bacteremia: a descriptive qualitative study2025