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December 23, 2025JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIAOpen Access

Effect of Combined Angiotensin-Converting Enzyme Inhibitor and Calcium Channel Blocker Therapy on Blood Glucose Level in Sprague-Dawley Rats

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Authors

GMGrace Valentina MulianingtyasHNHotlina Nainggolan

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Overview

This experiment demonstrates how calcium channel blocker therapy affects blood glucose in rats, suggesting implications for hypertension treatment.

Key Points

  • The aim is to evaluate the effect of combining ACE inhibitor and calcium channel blocker on blood glucose levels in rats.
  • Twenty-five Sprague-Dawley rats were used, divided into groups: normal, negative control, amlodipine, captopril, combination.
  • The treatment lasted for 21 days with blood glucose measured weekly.
  • A significance level was set at p<0.05 for statistical analysis.
  • Amlodipine showed a significant effect on blood glucose with p=0.003.
  • The combination therapy also showed a significant result with p=0.046, but did not cause hyperglycemia.

Cite This Study

Mulianingtyas et al. (2025) studied this question.

synapsesocial.com/papers/6949ddb572f746a93d788f63https://doi.org/10.20473/jfiki.v12i32025.399-406
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Also Consider

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