September 10, 2025Kardiologiia

Multicenter Prospective Randomized, Double-Blind, Placebo-Controlled Pharmacodynamic Study of The Additional Antihypertensive Effect of the Drug in Patients With Uncontrolled Arterial Hypertension Against the Background of Taking Renin-Angiotensin-Aldosterone System Blockers

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Discussion

Randomized trial demonstrates better blood pressure reduction in patients on ACE inhibitors, suggesting captopril's role in hypertension management.

Captopril led to a significant decrease in systolic blood pressure compared to placebo.
At one hour, the mean reduction in systolic BP was 22.0 mm Hg for captopril and 11.8 mm Hg for placebo.
The trial included 114 patients, all with poorly controlled arterial hypertension on ACE inhibitors or ARBs.
Captopril as an additional therapy may be effective for patients not responding well to existing antihypertensive medications.

Gilyarevskiy et al. (2025) studied this question.

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September 10, 2025Kardiologiia

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Authors

Randomized trial demonstrates better blood pressure reduction in patients on ACE inhibitors, suggesting captopril's role in hypertension management.

Captopril led to a significant decrease in systolic blood pressure compared to placebo.
At one hour, the mean reduction in systolic BP was 22.0 mm Hg for captopril and 11.8 mm Hg for placebo.
The trial included 114 patients, all with poorly controlled arterial hypertension on ACE inhibitors or ARBs.
Captopril as an additional therapy may be effective for patients not responding well to existing antihypertensive medications.

Gilyarevskiy et al. (2025) studied this question.

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