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September 10, 2025World Journal of Advanced Research and Reviews

ACE Inhibitors vs ARBs in Hypertensive Diabetics: A systematic review of cardiovascular mortality and renal outcomes

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Authors

EAEdwin C. AgbezeMOMoshood OlatinwoMEMartha Emmanuel Ebiale

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Overview

Systematic review compares cardiovascular mortality and renal outcomes in patients on ace inhibitors and arbs.

Key Points

  • ACE inhibitors significantly reduce cardiovascular mortality compared to ARBs, with both classes lowering blood pressure effectively.
  • Evidence from randomized controlled trials suggests that while ACE inhibitors help preserve kidney function, ARBs offer comparable renal protection with better tolerability.
  • The systematic review highlights the importance of individualized treatment, recommending ACE inhibitors as the first-line therapy when suitable for hypertensive diabetics.
  • Further large-scale trials are necessary to enhance clinical decision-making, especially for patients with chronic kidney disease.

Cite This Study

Agbeze et al. (2025) studied this question.

synapsesocial.com/papers/68c23c66b210217d64789993https://doi.org/10.30574/wjarr.2025.27.3.3125
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  4. 4Renoprotective Effects of RAAS Inhibitors in Patients with Diabetic Nephropathy: A Comprehensive Meta-Analysis of Randomized Controlled Trials2025 · 1 citations
  5. 5RAAS Inhibitors for the Primary Prevention of CKD in Type 1 and Type 2 Diabetes: A Systematic Review and Meta-analysis2026