September 5, 2025European Journal of Case Reports in Internal MedicineOpen Access

ineage switch of adult B-cell acute lymphoblastic leukaemia to acute myeloid leukaemia following B-cell-directed therapy

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Authors

OMOscar Felipe Borja MontesUniversity of Florida DHDarrell D. Horton ATAlejandro Toro-Pedroza

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Implication

Case report reveals a lineage switch from B-cell acute lymphoblastic leukaemia to acute myeloid leukaemia, suggesting risks of B-cell-targeted therapies.

Key Points

The patient switched from b-cell acute lymphoblastic leukaemia to acute myeloid leukaemia after treatment.
Initial treatment with blinatumomab resulted in remission, but subsequent relapses occurred after both therapies.
Bone marrow biopsy showed residual B-ALL and features of acute monocytic leukaemia.
This case highlights the risks associated with b-cell directed therapies, necessitating careful monitoring.

Cite This Study

Montes et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477a1b5 https://doi.org/10.12890/2025_005724

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Implication

Case report reveals a lineage switch from B-cell acute lymphoblastic leukaemia to acute myeloid leukaemia, suggesting risks of B-cell-targeted therapies.

ineage switch of adult B-cell acute lymphoblastic leukaemia to acute myeloid leukaemia following B-cell-directed therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

ineage switch of adult B-cell acute lymphoblastic leukaemia to acute myeloid leukaemia following B-cell-directed therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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