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December 8, 2025BloodOpen Access

Acute Myeloid Leukemia mortality in u.S. older adults: A 45-year nationwide analysis with forecasting through 2050

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SDSafi Ur Rehman Daim

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Overview

Analysis reveals rising mortality trends in older adults with acute myeloid leukemia, highlighting significant disparities by race and forecasting continued increases through 2050.

Key Points

  • Acute myeloid leukemia mortality in older adults shows an alarming rising trend, with disparities based on race.
  • From 1979 to 2023, the age-adjusted mortality rate for AML increased from 107.8 to 149.2 per million.
  • Joinpoint regression was utilized to assess mortality trends across demographic groups in this longitudinal analysis.
  • Forecasting models predict that age-adjusted mortality rates will continue to rise, indicating a growing public health concern.

Cite This Study

Safi Ur Rehman Daim (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e45chttps://doi.org/10.1182/blood-2025-1633
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Changing burden of Acute Myeloid Leukemia in the United States: A 23-year national analysis2025
  2. 2Acute Myeloid Leukemia and sepsis-related mortality in the United States (U.S.) older adults: Nationwide trends and disparities over 25 years (1999 – 2023)2025
  3. 3Temporal trends and demographic disparities in myelodysplastic syndrome-associated mortality in Acute Myeloid Leukemia patients in the United States: A population-based analysis (1999–2023)2025
  4. 4Trends in Acute Myeloid Leukemia mortality among patients with myelodysplastic syndrome in the United States (1999–2024): A CDC wonder database analysis2025
  5. 5Comparative trends in mortality from acute lymphoblastic and Acute Myeloid Leukemia in the United States: A CDC wonder analysis (1999–2020)2025