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December 8, 2025Blood

Trends in Acute Myeloid Leukemia mortality among patients with myelodysplastic syndrome in the United States (1999–2024): A CDC wonder database analysis

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ARAditya Keerthi Rayapureddy

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Overview

Retrospective analysis shows mortality trends in acute myeloid leukemia due to myelodysplastic syndrome, highlighting regional disparities.

Key Points

  • Mortality trends for acute myeloid leukemia indicate a slight decline, with an age-adjusted mortality rate of 13.0 per 100,000 by 2024.
  • Joinpoint regression analysis identified a notable annual percent change of 3.17 from 1999 to 2009 in AML patients with myelodysplastic syndrome.
  • Analysis using the CDC WONDER database revealed significant demographic differences and higher mortality rates among males and non-Hispanic Whites.
  • Findings call for targeted interventions to address disparities in acute myeloid leukemia mortality rates across different regions.

Cite This Study

Aditya Keerthi Rayapureddy (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5bdhttps://doi.org/10.1182/blood-2025-6913
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