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December 8, 2025BloodOpen Access

Temporal trends and demographic disparities in myelodysplastic syndrome-associated mortality in Acute Myeloid Leukemia patients in the United States: A population-based analysis (1999–2023)

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Authors

ADAllah DadMAMuhammad ArhamMVMaha Veer

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Overview

Population-based analysis reveals trends in mortality and risk factors in acute myeloid leukemia patients across gender and racial groups.

Key Points

  • Mortality rates for acute myeloid leukemia significantly declined, showing a 15.6% reduction from 1999 to 2023.
  • The average annual mortality rate for males decreased from 22.5 to 17.4 per million, while females saw a modest decline from 9.6 to 8.6 per million.
  • Subgroup analyses based on gender and race indicate disparities in acute myeloid leukemia outcomes, particularly among Black individuals and rural populations.
  • Projections suggest without targeted interventions, mortality rates may begin to rise again, highlighting the need for focused public health strategies.

Cite This Study

Dad et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfcahttps://doi.org/10.1182/blood-2025-7367
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends and disparities in myelodysplastic Syndrome–Associated mortality in the u.S. from 1999 to 2020: A population-based study using the CDC wonder database2025
  2. 2Trends in Acute Myeloid Leukemia mortality among patients with myelodysplastic syndrome in the United States (1999–2024): A CDC wonder database analysis2025
  3. 3Two-decade trends and future projections of heart failure mortality in Myelodysplastic Syndromes: A nationwide population-based study (1999–2030)2025
  4. 4Two decades of infectious mortality in Myelodysplastic Syndromes: An analysis from the CDC wonder database2025
  5. 5Blood and filters: The intersection of myelodysplastic syndrome and renal failure in u.S. mortality trends (1999–2023)2025