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December 8, 2025BloodOpen Access

Dynamic monitoring of circulating tumor DNA for real-time risk assessment in early-stage natural killer/t-cell lymphoma

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Authors

HHHe HuangLZLiqun ZouHZHong Yu Zhang

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Overview

Analysis reveals that circulating tumor DNA dynamics correlate with progression-free survival in patients with early-stage NKTCL, suggesting a potential for personalized treatment strategies.

Key Points

  • Dynamic monitoring of circulating tumor DNA shows significant correlations with progression-free survival in early-stage NKTCL.
  • Patients achieving negative circulating tumor DNA status during treatment phases displayed better outcomes: 5-year progression-free survival rates showed trends across phenotypes.
  • Utilization of multi-variable analysis revealed distinct phenotypes in circulating tumor DNA responses was predictive of patient prognosis.
  • Research supports the implementation of circulating tumor DNA monitoring in clinical practice to enhance risk-based treatment strategies for NKTCL.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e44bhttps://doi.org/10.1182/blood-2025-1745
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  5. 5Dynamic Profiling of Cell Free Tumour DNA in Aggressive B‐Cell Lymphoma From Diagnosis to Transformation at Relapse2025 · 1 citations