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August 1, 2025eJHaemOpen Access

Dynamic Profiling of Cell Free Tumour DNA in Aggressive B‐Cell Lymphoma From Diagnosis to Transformation at Relapse

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Authors

MWMark WalthamJWJonathan WongGPGalina Polekhina

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Overview

Evaluation of cell free tumour DNA reveals aggressive B-cell lymphoma dynamics, suggesting molecular profiling aids treatment response.

Key Points

  • Early molecular response predicts end-of-treatment complete metabolic response in aggressive B-cell lymphoma.
  • Somatic mutations were detected in all patients, highlighting the potential of ctDNA for precise profiling.
  • Analysis utilized next generation sequencing of ctDNA to monitor disease burden dynamically during treatment.
  • These findings support the utility of molecular profiling, though ctDNA alone may not diagnose late relapses effectively.

Cite This Study

Waltham et al. (2025) studied this question.

synapsesocial.com/papers/68af35ddcf1dd9ea359e9e04https://doi.org/10.1002/jha2.70126
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  4. 4Integration of longitudinal ctdna MRD and PET/CT enhances prognostic stratification in newly diagnosed diffuse large B-cell lymphoma: A prospective multicenter study2025
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