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December 8, 2025BloodOpen Access

Comprehensive analysis of early ctdna kinetics following first cycle of R-CHOP in LBCL patients

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Authors

PRPhilippe RuminyJPJuliette PénichouxAMAnne Menard

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Overview

Clinical trial reveals distinct ctDNA kinetics post R-CHOP in LBCL patients, indicating prognosis potential.

Key Points

  • ctDNA kinetics shows distinct patterns that could clarify the prognosis in patients with large B cell lymphoma after treatment.
  • Median baseline ctDNA values were lower for certain patient groups, impacting their treatment response.
  • A latent class mixed model identified four patient classes based on ctDNA kinetics after R-CHOP treatment initiation.
  • Further investigation into genomic instability may support early identification of poor treatment responders.

Cite This Study

Ruminy et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db1fhttps://doi.org/10.1182/blood-2025-5319
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  1. 1Whole-genome sequencing (WGS)-based circulating tumor DNA (ctDNA) monitoring in diffuse-large B-cell lymphoma (DLBCL)2025
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  3. 3Longitudinal ctdna tracking by low-pass whole-genome sequencing during CD19 CAR-T cell therapy for B-cell lymphomas2025
  4. 4Dissecting clonal hematopoiesis in diffuse large B-cell lymphoma through multi-compartment genomic profiling2025
  5. 5Dynamic monitoring of circulating tumor DNA for real-time risk assessment in early-stage natural killer/t-cell lymphoma2025