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December 8, 2025Blood

Molecular stratification of relapse risk post-allogeneic hematopoietic stem cell transplantation in myeloid neoplasms with non-adverse risk cytogenetics

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Authors

ABAnmol BaranwalKHKhalil HassanHAHassan B. Alkhateeb

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Overview

Analysis reveals next generation sequencing predicts relapse incidence in myeloid neoplasms, highlighting mutation frequencies' significance for prognosis.

Key Points

  • Relapse risk was significantly stratified based on mutations in SF3B1 and FLT3, influencing patient outcomes.
  • The study involved 215 patients, revealing 50% relapse incidence in high-risk groups compared to 14% in low-risk groups.
  • Assessment included mutation frequencies evaluated through a decision tree approach, yielding distinct risk groups.
  • These findings imply the need for targeted therapies in non-adverse cytogenetic cohorts based on precise prognostic factors.

Cite This Study

Baranwal et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e42ehttps://doi.org/10.1182/blood-2025-6073
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Also Consider

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  1. 1Prognostic covariates associated with outcomes in patients with <i>NPM1</i>-mutated acute myeloid leukemia2025 · 3 citations
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  3. 3Frequency and Impact of Somatic Co-occurring Mutations on Post-Transplant Outcomes in Acute Myeloid Leukemia: A Multicenter Registry Analysis on Behalf of the EBMT ALWP2025
  4. 4Impact of induction response and co-mutations on transplant outcomes in AML with myelodysplasia-related gene mutations: A multicenter retrospective study2025
  5. 5Prognostic factors for newly diagnosed Acute Myeloid Leukemia with FLT3-TKD - a multicenter retrospective study2025