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August 19, 2025The OncologistOpen Access

Prognostic covariates associated with outcomes in patients with NPM1-mutated acute myeloid leukemia

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Authors

SYShunjie YuSYSen YangLHLijuan Hu

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Overview

Analysis of relapse-free survival in NPM1-mutated AML patients shows important prognostic factors, implying a need for tailored therapies.

Key Points

  • Poor relapse-free survival was linked to male sex and high WBC count in NPM1 mut/FLT3-ITDwt patients, highlighting their clinical relevance.
  • High-risk patients with NPM1 mutations can be classified based on specific genetic factors, aiding tailored treatment approaches.
  • Multivariate analyses showed significant associations with relapse-free survival based on genetic mutations and measurable residual disease.
  • This research emphasizes the need for individualized therapy in high-risk acute myeloid leukemia patients with NPM1 mutations.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68af35d5cf1dd9ea359e9a5ehttps://doi.org/10.1093/oncolo/oyaf257
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Value of Molecular and Clinical Features in Patients with NPM1 Gene Mutation in Acute Myeloid Leukemia2025 · 1 citations
  2. 2Prognostic impact of co-occurring mutations in NPM1-mutated Acute Myeloid Leukemia2025
  3. 3The presence of secondary type or DNMT3A mutations does not affect prognosis in NPM1 mutated AML treated with intensified fludarabine-high dose cytarabine and idarubicine (FLAI) induction regimen.2025
  4. 4Outcomes of patients with newly diagnosed acute myeloid leukemia with FLT3-tyrosine kinase domain mutations: Prognostic implications of NPM1 co-mutation.2025 · 3 citations
  5. 5A Comprehensive Genomic Analysis of Nucleophosmin (NPM1) in Acute Myeloid Leukemia2025 · 2 citations