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September 5, 2025Open Access

Frequency and Impact of Somatic Co-occurring Mutations on Post-Transplant Outcomes in Acute Myeloid Leukemia: A Multicenter Registry Analysis on Behalf of the EBMT ALWP

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Authors

ABAli BazarbachiJGJacques‐Emmanuel GalimardIDIman Abou Dalle

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Overview

Registry analysis reveals somatic mutations affect overall survival and leukemia-free survival in AML, suggesting distinct mutation groups.

Key Points

  • Patients with somatic mutations in AML experience varied overall survival outcomes post-transplant.
  • Somatic mutations such as TP53 negatively impact leukemia-free survival and overall survival in allografted patients.
  • Allogeneic hematopoietic cell transplantation can overcome adverse risks associated with certain mutation groups.
  • Next generation sequencing identified groups of mutations that carry distinct prognostic implications for AML patients.

Cite This Study

Bazarbachi et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477f730https://doi.org/10.21203/rs.3.rs-7375987/v1
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