Addition of thiotepa to total body irradiation-based conditioning in allogeneic hematopoietic stem cell transplantation for relapsed/refractory acute leukemia and lymphoma: a propensity score-matched retrospective study
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Key Points
The study aims to evaluate the impact of adding thiotepa to TBI-based conditioning on survival and relapse rates in patients with relapsed/refractory acute leukemia and lymphoma.
Single-center retrospective analysis from 2020 to 2025
Included patients were matched by propensity score (1:2) based on 9 covariates
Primary endpoints assessed were overall survival and disease-free survival using Kaplan-Meier and Fine-Gray methods.
Overall survival was comparable: HR = 0.901, 95% CI 0.569–1.425, P = 0.655
Disease-free survival was comparable: HR = 0.809, 95% CI 0.504–1.299, P = 0.380
1-year relapse incidence was lower with TBI + TT: 6.7% vs. 17.8%, Gray’s P = 0.035, multivariable sHR = 0.280, 95% CI 0.083–0.942, P = 0.040.
Discussion
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Implication
Retrospective study evaluates thiotepa's effect on outcomes in R/R leukemia during transplant conditioning, suggesting lower relapse risk.