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December 8, 2025BloodOpen Access

DNA-proximal MYB phosphorylation is required for oncogenic transcription in acute myeloid leukemia

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Authors

SCShuyuan ChengMUMasahiro UniRKRichard P. Koche

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Overview

Investigation reveals MYB phosphorylation is crucial for transcription and survival in acute myeloid leukemia, suggesting therapeutic targets for intervention.

Key Points

  • Phosphorylation of MYB at S11/S12 is crucial for oncogenic transcription in AML cells, driving their growth and survival.
  • Mass spectrometry identified unique PTMs of MYB, showcasing specific amino acid modifications essential for activation in leukemia.
  • MYB co-assembles with key transcription factors, forming complexes that regulate gene expression linked to AML progression.
  • Targeting MYB's phosphorylation and associated transcriptional circuits may provide novel therapeutic approaches for AML.

Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4aehttps://doi.org/10.1182/blood-2025-3239
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Investigating ribosome biogenesis in AML identifies MYB-binding protein 1A (MYBBP1A) as an essential regulator of leukemia cells2025
  2. 2Hypermethylation of the ribosomal DNA coding sequence and disordered transcription factor binding as hallmarks of acute myeloid leukemia2025
  3. 3Revealing oncogenic enhancer regulation by epigenomic profiling of multiple myeloma and plasma cell leukemia patient samples2025
  4. 4CBFβ-SMMHC–driven leukemogenesis requires enhanced RUNX1-DNA binding affinity in mice2025 · 2 citations
  5. 5Pre-malignant extracellular matrix drives leukemia transformation through reprogramming of pre-leukemic stem cells2025