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December 8, 2025Blood

Evaluating the efficacy of brief neurocognitive assessments in adults and adolescents with sickle cell disease

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Authors

LGLisbel GonzalezJRJohn L. ReaganPMPatrick T. McGann

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Overview

Prospective analysis shows the utility of neurocognitive assessments for identifying impairments in adults with sickle cell disease, implying a need for universal screening strategies.

Key Points

  • Initial data indicates that 55% of participants demonstrate impairments via the NIH Toolbox, enhancing early detection.
  • Statistical analysis compares results from three neurocognitive screening tools assessing various cognitive domains in patients with SCD.
  • Contributing factors such as age and genotype were evaluated alongside neurocognitive performance assessments.
  • The study suggests promising results for clinic-based neurocognitive screening, emphasizing feasibility and practicality.

Cite This Study

Gonzalez et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2f4https://doi.org/10.1182/blood-2025-7963
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Description of neurocognition in adult sickle cell disease patients using the NIH toolbox2025
  2. 2Multimodal neuroimaging and neurocognitive assessment in adolescents with and without sickle cell disease2025
  3. 3Demographic, neurocognitive, disease impact, and social characteristics of patients served by embedded neuropsychological services in an adult sickle cell clinic2025
  4. 4OS06.6.A DEVELOPING A SCREENING TOOL FOR COGNITIVE DEFICITS IN NEURO-ONCOLOGY ROUTINE CLINICAL PRACTICE2025
  5. 5Subclinical neurovascular injury and cognitive outcomes in adults with sickle cell disease: Prevalence and imaging correlates2025