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December 8, 2025BloodOpen Access

Multimodal neuroimaging and neurocognitive assessment in adolescents with and without sickle cell disease

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Authors

DWDavid K. WilsonSCSimon ChungSSSuzanne Saccente

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Overview

Neurocognitive assessment unveils executive function deficits in adolescents with sickle cell disease, suggesting the need for targeted interventions.

Key Points

  • Adolescents with sickle cell disease exhibited significantly poorer executive function than controls, indicating underlying neurodevelopmental challenges.
  • Mean executive function scores were 89 for patients compared to 109 for controls, with p-value at 0.006.
  • Comprehensive neurocognitive assessment and multimodal MRI highlighted cerebral perfusion and structural brain differences linked to deficits.
  • Findings suggest that interventions during adolescence could mitigate executive function disruptions seen in sickle cell disease.

Cite This Study

Wilson et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9a3https://doi.org/10.1182/blood-2025-2968
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