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December 8, 2025BloodOpen Access

Description of neurocognition in adult sickle cell disease patients using the NIH toolbox

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Authors

IRIris RahmanTCTerrell CoringDQDevona Quasie-woode

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Overview

Prospective observational study shows decreased neurocognition, particularly in executive function, among adults with sickle cell disease, indicating clinical implications for management.

Key Points

  • Neurocognition is significantly lower in adults with sickle cell disease compared to age-matched controls, highlighting potential interventions.
  • Specifically, cognitive tests revealed deficits in executive function, episodic memory, and working memory among the patient cohort.
  • Prospective observational study conducted at a single center over 18 months using the NIH toolbox for comprehensive cognitive assessments.
  • Findings emphasize the need for early neurocognitive evaluation in sickle cell disease management, especially relating to acute chest syndrome.

Cite This Study

Rahman et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db05https://doi.org/10.1182/blood-2025-4716
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