December 8, 2025BloodOpen Access

Contact-free single cell assay for assessing RBC mechanical properties using brillouin microscopy: Evaluation of anti-sickling therapeutics

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Authors

AAAishwarya AnandUniversity of Maryland, Baltimore JLJennie Y. LawUniversity of Maryland, Baltimore DBDaniel F. BennettUniversity of Maryland, Baltimore

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Implication

Contact-free imaging demonstrates improved deformability in sickle cell disease RBCs with 5-Hydroxymethylfurfural, suggesting new therapeutic potential.

Key Points

Significant improvement in sickle RBC deformability observed with 5-Hydroxymethylfurfural treatment.
Brillouin frequency shift significantly decreased at both 2.5 mM and 5 mM doses under various oxygen conditions.
Assessment utilized brillouin microscopy in a controlled environmental chamber with density gradient centrifugation for RBCs.
Study highlights the potential for anti-sickling therapeutics to enhance biomechanics in sickle cell disease.

Cite This Study

Anand et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2d0 https://doi.org/10.1182/blood-2025-6490

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Implication

Contact-free imaging demonstrates improved deformability in sickle cell disease RBCs with 5-Hydroxymethylfurfural, suggesting new therapeutic potential.

Contact-free single cell assay for assessing RBC mechanical properties using brillouin microscopy: Evaluation of anti-sickling therapeutics

Discussion

Member takes

Implication

Key Points

Cite This Study

Contact-free single cell assay for assessing RBC mechanical properties using brillouin microscopy: Evaluation of anti-sickling therapeutics

Discussion

Member takes

Implication

Key Points

Cite This Study

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