August 19, 2025MicromachinesOpen Access

A Microfluidic Approach for Assessing the Rheological Properties of Healthy Versus Thalassemic Red Blood Cells

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Automated microfluidic assessment reveals decreased RBC deformability in thalassemia, indicating potential diagnostic use.

RBC deformability is crucial for circulation, and this method shows significant differences between healthy and thalassemic cells.
Deformability was reduced in thalassemic RBCs, particularly within 4 µm channels, highlighting diagnostic potential for hematological disorders.
Automated microfluidic techniques allowed for precise assessment of RBCs, utilizing high-speed imaging at 15,000 fps for detailed analysis.
This platform offers a standardized approach for evaluating RBC mechanics, uncovering new recovery dynamics and clinical implications.

Jiang et al. (2025) studied this question.

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